Severe Vulvovaginal Candidiasis.

Recurrent VVC is defined as four or more episodes of symptomatic VVC annually. Non-albicans Candida taxonomic category are found in 10% to 20% of persons with recurrent VVC, so vaginal cultures should be obtained to confirm non-albicans kind that are not as responsive to conventional therapies. Although each photographic film of recurrent VVC may respond to a position temporal property therapy of oral or topical agents, experts recommend a longer continuance of initial therapy such as 7 to 14 days of topical therapy or 150 mg oral administered once and repeated 3 days later for a sum of two doses. A wrongdoing regimen for 6 months has shown to be effective, but 30% to 40% of persons will have recurrent disease once care therapy is discontinued. The recommended 6-month support regimens include clotrimazole (Gyne-Lotrimin) 500 mg vaginal suppositories once weekly; ketoconazole (Nizoral) 100 mg once daily; fluconazole (Diflucan) 100 to 150 mg once weekly; and itraconazole(Sporanox) 400 mg once monthly or 100 mg once daily.